Development of Novel Organic Reactions
Development of Efficient Synthetic Routes
Asymmetric Synthesis of Azasugars Using Chlorosulfonyl Isocyanate (CSI) Reaction
Development of Novel PTK6, HIF, and HDAC Inhibitors
학력
(학사) 서울대학교 약학대학 (1977)
(석사) 서울대학교 약학대학 (1981)
(박사) 미국 UCLA 대학교 화학과 (1989)
약력/경력
한국유기합성학회 회장 (2019)
경기도 경제과학진흥원 바이오센터 센터장 (2016-2018)
대한약학회 약품화학분과회 회장 ((2014)
대한약학회 사무총장 (2013-1014)
미국 UCLA대학교 화학과 교환교수(2001-2002)
성균관대학교 약학대학 약학과 교수 (1993-현재)
동덕여자대학교 약학대학 약학과 조교수 (1990-1993)
미국 Harvard대학교 박사후연구원 (1989-1990)
학술지 논문
(2023)
Synthesis and biological evaluation of novel N-benzyltriazolyl-hydroxamate derivatives as selective histone deacetylase 6 inhibitors.
BIOORGANIC & MEDICINAL CHEMISTRY.
79,
1
(2023)
Synthesis and evaluation of ent-Conduramine C-1 derivatives as α-glucosidase inhibitors via CSI-mediated amination reaction.
CARBOHYDRATE RESEARCH.
524,
1
(2022)
Total synthesis of a-1-C-propyl-3,6-di-epi-nojirimycin and polyhydroxyindolizidine alkaloids via regio- and diastereoselective amination of anomeric acetals.
TETRAHEDRON.
116,
1
(2022)
Total Synthesis of Eliglustat via Diastereoselective Amination of Chiral para-Methoxycinnamyl Benzyl Ether.
MOLECULES.
27,
8
(2021)
Synthesis and biological evaluation of novel purinyl quinazolinone derivatives as PI3K8-specific inhibitors for the treatment of hematologic malignancies.
BIOORGANIC MEDICINAL CHEMISTRY.
45,
1
(2020)
Synthesis and biological evaluation of quinoxaline derivatives as specific c-Met kinase inhibitors.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS.
30,
13
(2020)
Total synthesis of chromanol 293B and cromakalim via stereoselective amination of chiral benzylic ethers.
TETRAHEDRON LETTERS.
61,
5
(2019)
Site-Selective C-H Alkylation of Diazine N-Oxides Enabled by Phosphonium Ylides.
ORGANIC LETTERS.
21,
16
(2019)
Structure-activity relationship study of thiazolyl-hydroxamate derivatives as selective histone deacetylase 6 inhibitors.
BIOORGANIC & MEDICINAL CHEMISTRY.
27,
15
(2019)
Synthesis of (2H)-Indazoles from Azobenzenes Using Paraformaldehyde as a One-Carbon Synthon.
ADVANCED SYNTHESIS & CATALYSIS.
361,
7
(2018)
Dual Role of Anthranils as Amination and Transient Directing Group Sources: Synthesis of 2-Acyl Acridines.
ORGANIC LETTERS.
20,
13
(2017)
Rhodium(III)-Catalyzed Diastereoselective Synthesis of 1-Aminoindanes via C-H Activation.
ADVANCED SYNTHESIS & CATALYSIS.
359,
22
(2017)
Synthesis and Anticancer Evaluation of 2,3-Disubstituted Indoles Derived from Azobenzenes and Internal Olefins.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY.
42
(2017)
Total Synthesis and Anti-inflammatory Evaluation of Penchinone A and Its Structural Analogues.
JOURNAL OF ORGANIC CHEMISTRY.
82,
21
(2017)
Total synthesis of (-)-codonopsinine via regioselective and diastereoselective amination using chlorosulfonyl isocyanate.
TETRAHEDRON.
73,
30
(2017)
Synthesis and Cytotoxic Evaluation of N-Aroylureas through Rhodium(III)-Catalyzed C-H Functionalization of Indolines with Isocyanates.
ADVANCED SYNTHESIS & CATALYSIS.
359,
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(2017)
Synthesis and anti-inflammatory evaluation of N-sulfonyl anthranilic acids via Ir(III)-catalyzed C-H amidation of benzoic acids.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS.
27,
10
(2017)
Rhodium-Catalyzed [3+2] Annulation of Cyclic N-Acyl Ketimines with Activated Olefins: Anticancer Activity of Spiroisoindolinones.
JOURNAL OF ORGANIC CHEMISTRY.
82,
7
(2017)
Site-selective Cp* Rh(III)-catalyzed C-H amination of indolines with anthranils.
ORGANIC CHEMISTRY FRONTIERS.
4,
2
(2017)
Installation of alpha-ketocarboxylate groups to C7-position of indolines via C-H addition and oxidation approach under ruthenium catalysis.
TETRAHEDRON.
73,
13
단행본
(2019)
의약화학.
신일서적.
공동
(2013)
무기 및 방사성 의약품학.
동명사.
공동
(2013)
실험의약품합성학.
청문각.
주저자
(2011)
의약화학.
신일북스.
공동
(2011)
의약품합성학 (Synthetic Pharmaceutical Chemistry).
동명사.
공동
(2003)
The Korean Pharmacopoeia.
약업신문.
공동
(2002)
무기의약품화학실험서.
동명사.
공동
(2001)
의약화학.
신일상사.
공동
(2001)
무기의약품화학.
동명사.
공동
(2000)
무기약품제조화학.
도서출판 경원.
공동
(2000)
실험유기의약품화학.
청문각.
공동
(2000)
유기의약품화학.
동명사.
공동
(2000)
무기약품제조화학.
경원미디어.
공동
(1999)
무기의약품제조화학.
도서출판 경원.
공동
(1999)
유기의약품화학.
동명사.
공동
(1998)
유기의학품 화학.
공동
특허/프로그램
신규한 HDAC6 억제제를 이용한 치매 또는 인지장애 예방 또는 치료용 약학적 조성물.
10-2018-0045283.
20200212.
대한민국
(S)-다포세틴 염산염의 제조방법.
10-2012-0010093.
20140328.
대한민국
(1R,2R,3R)-3-아미노사이클로펜탄-1,2-디올을 포함하는 항알러지용 조성물.
10-2011-0032771.
20130829.
대한민국
(1S,2S,3S,4S)-5-아미노사이클로펜탄-1,2,3,4-테트라올을 포함하는 항비만 조성물.
10-2010-0007547.
20111012.
대한민국
신규 벤조퓨란 유도체와 이를 포함하는 부정맥 예방 및 치료용 조성물.
10-0760676.
20070914.
대한민국
신규 벤조푸란 유도체를 포함하는 부정맥 예방용 식품.
10-0752613.
20070821.
대한민국
Pharmaceutical compositions comprising chelidonine or derivatives thereof.
CN 1254243 c.
20061117.
중국
아피쿨라렌 A의 제조방법.
10-0632696.
20060929.
대한민국
소라렌 또는 그 유도체를 포함하는 부정맥의 예방 및 치료용 조성물.
10-0627828.
20060918.
대한민국
항암활성이 있는 티몰 유도체 및 이를 포함하는 항암제.
10-0623095.
20060905.
대한민국
Pharmaceutical composition comprising chelidonine or derivatives thereof.
US 6,887,882 B2.
20050503.
미국
Apicidin-derivatives, there synthetic method, and antitumor compositions containing the same..
US 6,831,061 B2.
20041214.
미국
Thymol derivatives having anti-tumor activity, and anti-cancer agent comprising the same.
US6,255,517B1.
20010703.
미국
Asiatic acid derivative, it's manufacturing method and dermatological
agent containing it..
GB 2 309 695.
19990301.
미국
수상/공훈
한국유기합성학회 학술대상 (2019)
보건복지부장관 표창장 (2014)
한국유기합성학회 학술상 (2013)
과학기술부 장관 표창장 (2001)
학술회의논문
(2019)
Regioselective and Stereoselective Amination with Use of Chlorosulfonyl Isocyanate and Its Application to Synthesis of N-Containing Bioactive Compounds.
International Symposium on Pharmaceutical Sciences in Sendai 2019.
일본
(2019)
Asymmetric Total Synthesis of (-)-Bugecinine.
2019 Fall International Convention of the Pharmaceutical Society of Korea.
대한민국
(2019)
Synthesis of conduramine C1 derivatives as glucosidase inhibitors using chlorosulfonyl isocyanate.
2019 Fall International Convention of the Pharmaceutical Society of Korea.
대한민국
(2019)
Total synthesis of quinolizidine alkaloid using chlorosulfonyl isocyanate (CSI)-mediated amination reaction at anoeric acetal of sugars.
2019 Fall International Convention of the Pharmaceutical Society of Korea.
대한민국
(2019)
Synthesis and biological evaluation of thiazole hydroxamate derivatives as HDAC6 inhibitor.
20th Tetrahedron Symposium.
태국
(2019)
Total Synthesis of (+)-DMDP and (+)-hyacinthacine A2.
2019 ACS National Meeting.
미국
(2017)
Asymmetric Total synthesis of (+)DMDP and Hyacinthacine A2 using chlorosulfonyl isocyanate via a highly regioselective and diastereoselective allylic amination.
18th Tetrahedron Symposium.
헝가리
(2017)
Divergent total synthesis of D-ribo-phytosphingosine and L-ribophytosphingosine from D-ribose.
18th Tetrahedron Symposium.
헝가리
(2017)
Synthesis and Biological Evaluation of Hydroxamate Compounds as HDAC6 Inhibitors.
10th Joint Meeting on Medicinal Chemistry.
크로아티아
(2017)
Asymmetric Synthesis of (-)-Codonopsinine using Chlorosulfonyl Isocyanate via CSI-mediated Regio- and Stereoselective Amination.
제13회 대한약학회 약품화학분과학회 워크샵.
대한민국
(2017)
Synthesis, Molecular Docking and Biological Evaluation of Hydroxamates as HDAC6 Inhibitors.
제13회 대한약학회 약품화학분과학회 워크샵.
대한민국
(2017)
Asymmetric Synthesis of (-)-Codonopsinine using Chlorosulfonyl Isocyanate via a Regioselective and Stereoselective Amination.
2017 International Conventional of The Pharmaceutical Society Korea.
대한민국
(2017)
Design, Synthesis and Biological Evaluation of Hydroxamate Compounds as HDAC6 Inhibitors.
2017 International Conventional of The Pharmaceutical Society Korea.
대한민국
(2017)
Synthesis of Aminocyclopentitol Analogues via CSI-Mediated Stereoselective Amination.
2nd european organic chemistry congress.
네덜란드
(2016)
Synthesis and Biological Evaluation of Hydroxamate Compounds as HDAC6 Inhibitors.
대한약학회 창립 70주년 국제학술대회.
대한민국
(2016)
Total Synthesis of Conduramine D-1 via C냐-Mediated a highly regioselective and diastereoselective allylic amination.
대한약학회 창립 70주년 국제학술대회.
대한민국
(2016)
Total Synthesis of Conduramine D-1.
17th Tetrahedron symposium.
스페인
(2016)
Total synthesis of DMDP and Hyacinthacine A2 via a Highly Regioselective and Diastereoselective Allylic Amination using Chlorosulfonyl Isocyanate.
17th Tetrahedron symposium.
스페인
(2016)
Total Synthesis of (+)-Hyacinthacine A2 and Its Derivatives via CSi-Mediated Stereoselective Amination.
International convention of The Pharmaceutical Society of Korea.
대한민국
(2016)
Total Synthesis of (+)-valienamine derivatives using chlorosulfonyl isocyanate via stereoselective amination.
International convention of The Pharmaceutical Society of Korea.
대한민국
